Early printing houses (near the time of Gutenberg) were run by "master printers." These printers owned shops, selected and edited manuscripts, determined the sizes of print runs, sold the works they produced, raised capital and organized distribution. Some master printing houses, like that of Aldus Manutius, became the cultural centre for literati such as Erasmus.

* Print shop apprentices: Apprentices, usually between the ages of 15 and 20, worked for master printers. Apprentices were not required to be literate, and literacy rates at the time were very low, in comparison to today. Apprentices prepared ink, dampened sheets of paper, and assisted at the press. An apprentice who wished to learn to become a compositor had to learn Latin and spend time under the supervision of a journeyman.
* Journeyman printers: After completing their apprenticeships, journeyman (so called from the French "journée" for day) printers were free to move employers. This facilitated the spread of printing to areas that were less print-centred.
* Compositors: Those who set the type for printing.
* Pressmen: the person who worked the press. This was physically labour intensive.

The earliest-known image of a European, Gutenberg-style print shop is the Dance of Death by Matthias Huss, at Lyon, 1499. This image depicts a compositor standing at a compositor's case being grabbed by a skeleton. The case is raised to facilitate his work. The image also shows a pressman being grabbed by a skeleton. At the right of the printing house a bookshop is shown.

Financial aspects

Court records from the city of Mainz document that Johannes Fust was, for some time, Gutenberg's financial backer.

By the sixteenth century jobs associated with printing were becoming increasingly specialized. Structures supporting publishers were more and more complex, leading to this division of labour. In Europe between 1500 and 1700 the role of the Master Printer was dying out and giving way to the bookseller—publisher. Printing during this period had a stronger commercial imperative than previously. Risks associated with the industry however were substantial, although dependent on the nature of the publication.

Bookseller publishers negotiated at trade fairs and at print shops. Jobbing work appeared in which printers did menial tasks in the beginning of their careers to support themselves.

1500–1700: Publishers developed several new methods of funding projects.

1. Cooperative associations/publication syndicates—a number of individuals shared the risks associated with printing and shared in the profit. This was pioneered by the French.
2. Subscription publishing—pioneered by the English in the early 17th century. A prospectus for a publication was drawn up by a publisher to raise funding. The prospectus was given to potential buyers who signed up for a copy. If there were not enough subscriptions the publication did not go ahead. Lists of subscribers were included in the books as endorsements. If enough people subscribed a reprint might occur. Some authors used subscription publication to bypass the publisher entirely.
3. Installment publishing—books were issued in parts until a complete book had been issued. This was not necessarily done with a fixed time period. It was an effective method of spreading cost over a period of time. It also allowed earlier returns on investment to help cover production costs of subsequent installments.

The Mechanick Exercises, by Joseph Moxon, in London, 1683, was said to be the first publication done in installments.

Publishing trade organizations allowed publishers to organize business concerns collectively. Systems of self-regulation occurred in these arrangements. For example, if one publisher did something to irritate other publishers he would be controlled by peer pressure. Such systems are known as cartels, and are in most countries now considered to be in restraint of trade. These arrangements helped deal with labour unrest among journeymen, who faced difficult working conditions. Brotherhoods predated unions, without the formal regulations now associated with unions.

In most cases, publishers bought the copyright in a work from the author, and made some arrangement about the possible profits. This required a substantial amount of capital in addition to the capital for the physical equipment and staff. Alternatively, an author who had sufficient money would sometimes keep the copyright himself, and simply pay the printer for the production of the book. For further developments, see main article:copyright